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Article

Causal effect of blood osteocalcin on the risk of Alzheimer's disease and the mediating role of energy metabolism.

Translational psychiatry - 20 May 2024

Guo Xingzhi, Yang Yu-Ying, Zhou Rong, Tian Ge, Shan Chang, Liu Jian-Min, Li Rui

Abstract excerpt

Growing evidence suggests an association between osteocalcin (OCN), a peptide derived from bone and involved in regulating glucose and lipid metabolism, and the risk of Alzheimer's disease (AD). However, the causality of these associations and the underlying mechanisms remain uncertain. We utilized a Mendelian randomization (MR) approach to investigate the causal effects of blood OCN levels on AD and to assess...

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Source

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Identifiers

PMID: 38769320
DOI: 10.1038/s41398-024-02924-w
PMCID: PMC11106250

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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