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A Phenome-wide Association and Mendelian Randomization Study for Alzheimer's Disease: A Prospective Cohort Study of 502,493 Participants From the UK Biobank.

Biological psychiatry - 1 May 2023

Chen Shi-Dong, Zhang Wei, Li Yu-Zhu, Yang Liu, Huang Yu-Yuan, Deng Yue-Ting, Wu Bang-Sheng, Suckling John, Rolls Edmund T, Feng Jian-Feng, Cheng Wei, Dong Qiang, Yu Jin-Tai

Abstract excerpt

BACKGROUND: Considerable uncertainty remains regarding associations of multiple risk factors with Alzheimer's disease (AD). We aimed to systematically screen and validate a wide range of potential risk factors for AD. METHODS: Among 502,493 participants from the UK Biobank, baseline data were extracted for 4171 factors spanning 10 different categories. Phenome-wide association analyses and time-to-event analyses...

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PMID: 36788058
DOI: 10.1016/j.biopsych.2022.08.002

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