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Article

Investigation of the causal relationship between osteocalcin and dementia: A Mendelian randomization study

1 Oct 2023

Abstract excerpt

Objective: Basic medical studies have reported an improved effect of osteocalcin on cognition. We explored the causal link between osteocalcin and dementia via the implementation of Mendelian randomization methodology. Methods: Genome-wide association studies were employed to identify single nucleotide polymorphisms (SNPs) showing significant correlations with osteocalcin. Subsequently, A two-sample Mendelian...

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PMID: 37916108
DOI: 10.1016/j.heliyon.2023.e21073

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