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Causal Relationship Between Basal Metabolic Rate and Alzheimer’s Disease: A Bidirectional Two-sample Mendelian Randomization Study

10 Mar 2023

Abstract excerpt

Objective observational studies have shown that basal metabolic rate (BMR) decreases in patients with Alzheimer’s disease (AD), but the causal relationship between BMR and AD has not been established. We determined the causal relationship between BMR and AD by two-way Mendelian randomization (MR) and investigated the impact of factors associated with BMR on AD. We obtained BMR ( n = 454,874) and AD from a large...

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PMID: 36894827
DOI: 10.1007/s40120-023-00458-9

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