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Life's Essential 8, genetic susceptibility, and risk of cognitive impairment: results from an elder population-based cohort study.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2026

Wang Yutong, Lei Bowen, Jiang Ke, Chen Xin, Qu Yang, Song Xin, Dui Xinyang, Zhao Qingwen, Zhao XunYing, Zou Yanqiu, Ma Tianpei, Zhang Di, Xiao Jinyu, Fan Mengyu, Liao Jiaqiang, Long Lu, Zhang Tao, Wang Chuan, Li Jiayuan, Jiang Xia, Zhang Ben

Abstract excerpt

INTRODUCTION: The American Heart Association's Life's Essential 8 (LE8) framework has been linked to cognitive impairment, but evidence in Chinese older adults remains limited. METHODS: This cross-sectional study included 7469 adults aged ≥60 years from the West China Health and Aging Cohort. Modified Poisson regression with robust error variance was used to examine the associations of LE8 scores and genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42151709
DOI: 10.1002/alz.71437
PMCID: PMC13183593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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