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Physical frailty, genetic predisposition, and incident dementia: a large prospective cohort study.

Translational psychiatry - 27 May 2024

Gao Pei-Yang, Ma Ling-Zhi, Wang Xue-Jie, Wu Bang-Sheng, Huang Yi-Ming, Wang Zhi-Bo, Fu Yan, Ou Ya-Nan, Feng Jian-Feng, Cheng Wei, Tan Lan, Yu Jin-Tai

Abstract excerpt

Physical frailty and genetic factors are both risk factors for increased dementia; nevertheless, the joint effect remains unclear. This study aimed to investigated the long-term relationship between physical frailty, genetic risk, and dementia incidence. A total of 274,194 participants from the UK Biobank were included. We applied Cox proportional hazards regression models to estimate the association between...

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Aged
Dementia
Frailty
Genetic Predisposition to Disease
Incidence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proportional Hazards Models

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PMID: 38802408
DOI: 10.1038/s41398-024-02927-7
PMCID: PMC11130190

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