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Interplay of accelerated biological aging, lifestyle factors, and genetic susceptibility in cognitive function: a community study.

The journals of gerontology. Series A, Biological sciences and medical sciences - 5 Feb 2026

Ma Tianpei, Chen Xin, Zhao Qingwen, Xu Xinyin, Zhang Xingyu, Liu Xiaoxue, Zhuoma Diji, Hu Mengjie, Yan Haiyu, Lin Lei, Jiang Ke, Dui Xinyang, Zhao Xunying, Wu Xueyao, Xiao Jinyu, Jiang Xia, Zhang Tao, Fan Mengyu, Long Lu, Deng Ying, Liao Jiaqiang, Li Jiayuan

Abstract excerpt

Cognitive impairment is a significant health concern in aging populations, but the interplay between biological aging, lifestyle factors, and genetic susceptibility remains unclear. This study examined whether accelerated biological aging is associated with cognitive impairment, whether lifestyle modifies this association, and how genetic background influences these relationships in Chinese older adults. In this...

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PMID: 41389215
DOI: 10.1093/gerona/glaf277

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