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Association and prediction of Life's Essential 8 score, genetic susceptibility with MCI, dementia, and MRI indices: A prospective cohort study.

Journal of affective disorders - 1 Sept 2024

Wang Qi, Yu Ruihong, Dong Caiyun, Zhou Chunmiao, Xie Ziwei, Sun Huizi, Fu Chunying, Zhu Dongshan

Abstract excerpt

BACKGROUND: To examine the associations of Life's Essential 8 (LE8) and its predictive performance with mild cognitive impairment (MCI), dementia and brain MRI indices. METHODS: We used cohort data from UK Biobank. LE8 was categorized into low (<50 score), moderate (50-79 score), and high (≥80 score) levels. Cox regression models considering death as a competing risk were used to estimate the hazard ratios (HRs)...

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PMID: 38844164
DOI: 10.1016/j.jad.2024.06.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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