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Impact of genetic risk and lifestyles on cardiovascular disease-free and total life expectancy: a cohort study.

Genome medicine - 22 Jul 2025

Sun Dong, Sun Qiufen, Ding Yinqi, Yu Canqing, Sun Dianjianyi, Pang Yuanjie, Pei Pei, Yang Ling, Millwood Iona Y, Walters Robin G, Du Huaidong, Zhang Jun, Schmidt Dan, Chen Junshi, Chen Zhengming, Li Liming, Lv Jun

Abstract excerpt

BACKGROUND: Understanding the role of genetic risk and lifestyles on life expectancy (LE) without cardiovascular disease (CVD) and total LE may help optimize healthy aging strategies after taking genetic background into account. METHODS: The China Kadoorie Biobank recruited participants from five urban and five rural areas across China during 2004-2008 and followed them up till December 31, 2018. A polygenic risk...

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PMID: 40696436
DOI: 10.1186/s13073-025-01487-9
PMCID: PMC12285114

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