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Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study.

Investigative ophthalmology & visual science - 1 Apr 2025

Wang Wenxu, Ren Rui, Liu Yue, Ye Xingyue, Zhang Ru, Xi Linze, Wang Liying, Zhang Yao, Zhang Yi, Wang Difei

Abstract excerpt

Purpose: We determined the association between Life's Essential 8 (LE8) scores and AMD incidence and ascertained whether genetic susceptibility modifies it. Methods: This prospective cohort study included 268,634 UK Biobank study participants with high, moderate, or low cardiovascular health based on LE8 scores. High and low cardiovascular health corresponded to the lowest and highest cardiovascular disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40257787
DOI: 10.1167/iovs.66.4.54
PMCID: PMC12020978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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