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Relation of Life's Essential 8 to the genetic predisposition for cardiovascular outcomes and all-cause mortality: results from a national prospective cohort.

European journal of preventive cardiology - 26 Oct 2023

Zhang Junguo, Chen Ge, Habudele Zierdi, Wang Xiaojie, Cai Miao, Li Haitao, Gao Yanhui, Lip Gregory Y H, Lin Hualiang

Abstract excerpt

AIMS: To evaluate the independent, mediating, interactive, and associated effects of Life's Essential 8 (LE8) and genetic predisposition on the risk of cardiovascular outcomes and all-cause mortality. METHODS AND RESULTS: We retrieved a total of 254 783 individuals from the UK Biobank. LE8 was determined by eight metrics (nicotine exposure, physical activity, diet, sleep, body mass index, blood pressure, blood...

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PMID: 37228091
DOI: 10.1093/eurjpc/zwad179

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