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Article

Genetic and non-genetic factors associated with the phenotype of exceptional longevity & normal cognition.

Scientific reports - 5 Nov 2020

Han Bin, Chen Huashuai, Yao Yao, Liu Xiaomin, Nie Chao, Min Junxia, Zeng Yi, Lutz Michael W

Abstract excerpt

In this study, we split 2156 individuals from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) data into two groups, establishing a phenotype of exceptional longevity & normal cognition versus cognitive impairment. We conducted a genome-wide association study (GWAS) to identify significant genetic variants and biological pathways that are associated with cognitive impairment and used these results to...

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Identifiers

PMID: 33154391
DOI: 10.1038/s41598-020-75446-2
PMCID: PMC7645680

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