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Intrinsic Capacity, Polygenic Risk Score, APOE Genotype, and Risk of Dementia: A Prospective Cohort Study Based on the UK Biobank.

Neurology - 25 Jun 2024

Sun Mengtong, He Qida, Sun Na, Han Qiang, Wang Yu, Zhao Hanqing, Li Guoxian, Ma Ze, Feng Zhaolong, Li Tongxing, Yang Lichao, Shen Yueping

Abstract excerpt

BACKGROUND AND OBJECTIVES: The World Health Organization recently released a novel metric for healthy aging: intrinsic capacity (IC). The relationship between IC and the incidence of dementia, and its subtypes, is unknown. We aimed to analyze the relationship between IC and the incidence of dementia and its subtypes. Moreover, we tested whether genetic susceptibility to dementia could be modified by IC. METHODS:...

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PMID: 38843484
DOI: 10.1212/WNL.0000000000209452

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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