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Article

Shared Genetic Liability Between Heart Failure and Myocardial Infarction Revealed by Genome-Wide Cross-Trait Analysis.

Journal of cardiovascular pharmacology and therapeutics - 1 Jan 2026

Liu Ruikang, Sun Chiyun, Jiang Nan, Liu Yang, Li Jun, Zhang Fuyuan, Chen Cong, Liu Yiying, Qi Xiaodi, Guo Bingting, Yang Kai

Abstract excerpt

BackgroundThe extent and biological relevance of shared genetic architecture between myocardial infarction (MI) and heart failure (HF) remain incompletely understood.MethodsWe analyzed large-scale European-ancestry genome-wide association studies summary statistics for MI and HF. Genome-wide genetic correlation was estimated using linkage disequilibrium score regression, and polygenic overlap was quantified using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42141940
DOI: 10.1177/10742484261452728

Genes

BRAP
CDKN2B
CELSR2
MYOZ1
NBEAL1
SLC22A2
SLC22A3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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