Integrative genetic analysis reveals shared genetic architecture underlying coronary artery disease, CT-Defined coronary atherosclerosis, and cardiometabolic risk factors.

Abstract excerpt

Coronary artery disease (CAD), computed tomography-defined coronary atherosclerosis (CT-CA), and cardiometabolic risk factors (CMRFs) are epidemiologically intertwined, yet their shared genetic basis has been explored through pairwise analyses. A comprehensive framework integrating clinical disease, subclinical imaging phenotypes, and upstream risk factors simultaneously remains lacking. We integrated large-scale...

Topics

• Coronary Artery Disease
• Humans
• Polymorphism, Single Nucleotide
• Genome-Wide Association Study
• Cardiometabolic Risk Factors
• Tomography, X-Ray Computed
• Genetic Predisposition to Disease
• Microfilament Proteins