Article

Genome-wide association and multi-omic analyses reveal new mechanisms for Heart Failure

2019-09-17

Abstract excerpt

Heart failure is a major medical and economic burden in the healthcare system affecting over 23 million people worldwide. Although recent pedigree studies estimate heart failure heritability around 26%, genome-wide association studies (GWAS) have had limited success in explaining disease pathogenesis. We conducted the largest meta-analysis of heart failure GWAS to-date and replicated our findings in a comparable s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 35ebd272-8b53-5847-9136-787c44c797d1
DOI: 10.1101/19006510

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association and multi-omic analyses reveal new mechanisms for Heart FailureDOI 10.1101/19006510Read

Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure.Semantic proximity Read

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failureSemantic proximity Read

Genetics of heart failure.Semantic proximity Read

Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure.Semantic proximity Read

Integration of dilated cardiomyopathy genomics with transcriptomics from the human heart implicates regulatory molecular mechanismsSemantic proximity Read

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failureSemantic proximity Read

Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.Semantic proximity Read

The Genetic Factors Influencing Cardiomyopathies and Heart Failure across the Allele Frequency Spectrum.Semantic proximity Read

Genome-wide analysis of cardiac ventricular phenotypes reveals novel loci and therapeutic targets for heart failure.Semantic proximity Read

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.Semantic proximity Read

Assessing the role of rare pathogenic variants in heart failure progression by exome sequencing in 8,089 patientsSemantic proximity Read

Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.Semantic proximity Read