Genome-wide cross-trait analysis reveals immunogenetic pleiotropy between autoimmune diseases and myocardial infarction and prioritizes therapeutic targets.

doi:10.1016/j.atherosclerosis.2026.121849

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genome-wide cross-trait analysis reveals immunogenetic pleiotropy between autoimmune diseases and myocardial infarction and prioritizes therapeutic targets.

Atherosclerosis - 1 Sept 2026

Liao Chung-Chih, Hu Wu-Chen, Yang Shun-Fa, Li Jung-Miao

Abstract excerpt

BACKGROUND AND AIMS: Autoimmune diseases (ADs) are associated with increased myocardial infarction (MI) risk, suggesting shared genetic susceptibility. We systematically investigated the shared genetic architecture, pleiotropic loci, and candidate therapeutic targets linking ADs and MI. METHODS: We analyzed genome-wide association study summary statistics for 10 ADs and MI, primarily from European-ancestry...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Autoimmune Diseases
Share to Autoimmunity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Pleiotropy

Share to Linkage Disequilibrium

Share to Mendelian Randomization Analysis

Share to Myocardial Infarction

Share to Myocytes, Cardiac

Source

Open in PubMed

Identifiers

PMID: 42462659
DOI: 10.1016/j.atherosclerosis.2026.121849

Genes

SH2B3
ACAD10
TMEM116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.