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Article

APOE ε4 influences the widespread TDP-43 pathological subtype in sporadic amyotrophic lateral sclerosis.

Acta neuropathologica - 15 May 2026

Hatano Yuya, Nakahara Asa, Tada Mari, Kakita Akiyoshi, Onodera Osamu, Ishihara Tomohiko

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, most sporadic cases exhibiting TAR DNA-binding protein 43 (TDP-43) pathology. The anatomical distribution of TDP-43 pathology varies among patients; however, factors contributing to this heterogeneity remain unclear. Apolipoprotein E (APOE) ε4 is known to influence the spread of pathological protein in several neurodegenerative diseases,...

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Identifiers

PMID: 42141160
DOI: 10.1007/s00401-026-03029-y
PMCID: PMC13179199

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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