Article
Cognitive decline in amyotrophic lateral sclerosis: Neuropathological substrate and genetic determinants.
Brain pathology (Zurich, Switzerland) - 1 May 2021
Borrego-Écija Sergi, Turon-Sans Janina, Ximelis Teresa, Aldecoa Iban, Molina-Porcel Laura, Povedano Mónica, Rubio Miguel Angel, Gámez Josep, Cano Antonio, Paré-Curell Martí, Bajo Lorena, Sotoca Javier, Clarimón Jordi, Balasa Mircea, Antonell Anna, Lladó Albert, Sánchez-Valle Raquel, Rojas-García Ricard, Gelpi Ellen
Abstract excerpt
Cognitive impairment and behavioral changes in amyotrophic lateral sclerosis (ALS) are now recognized as part of the disease. Whether it is solely related to the extent of TDP-43 pathology is currently unclear. We aim to evaluate the influence of age, genetics, neuropathological features, and concomitant pathologies on cognitive impairment in ALS patients. We analyzed a postmortem series of 104 ALS patients and...
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