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Article

Apolipoprotein E Alleles Across the Spectrum of Frontotemporal Lobar Degeneration: A Systematic Review and Meta-Analysis.

International journal of molecular sciences - 29 Aug 2026

Liampas Ioannis, Polyviou Antonis, Demiri Silvia, Malataras Gerasimos, Oikonomakis Vasilis, Siokas Vasileios, Kargiotis Odysseas, Kefalopoulou Zinovia-Maria, Chroni Elisabeth, Dardiotis Efthimios

Abstract excerpt

We conducted a systematic review and meta-analysis of associations between apolipoprotein E (APOE) alleles and frontotemporal lobar degeneration (FTLD)-spectrum disorders. MEDLINE, Embase, CENTRAL, and Google Scholar were searched. APOE2 and APOE4 carrier status were compared between FTLD-spectrum disorders and healthy controls (HCs) or individuals with Alzheimer's disease (AD). Forty studies were included. APOE4...

Read the complete abstract on PubMed

Topics

Humans
Frontotemporal Lobar Degeneration
Alleles
Apolipoprotein E4
Apolipoproteins E

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Alzheimer Disease

Apolipoprotein E2

Frontotemporal Dementia

Genetic Predisposition to Disease

Supranuclear Palsy, Progressive

Source

Open in PubMed Open full text

Identifiers

PMID: 42737648
DOI: 10.3390/ijms27177752
PMCID: PMC13565894

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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