Article

Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies

2023-02-02

Abstract excerpt

TAR DNA-binding protein-43 (TDP-43) accumulation is the primary pathology underlying several neurodegenerative diseases. Charting the progression and heterogeneity of TDP-43 accumulation is necessary to better characterise TDP-43 proteinopathies, but current TDP-43 staging systems are heuristic and assume each syndrome is homogeneous. Here, we use data-driven disease progression modelling to derive a fine-grained...

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Literature Corpus work: 9ae26a0e-b34c-5b2c-802e-8af8f7a26635
DOI: 10.1101/2023.01.31.23285242

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