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Article

Genome-wide association study of neuropathological features in Lewy body disease.

Brain : a journal of neurology - 1 Aug 2025

Valentino Rebecca R, Koga Shunsuke, Soto-Beasley Alexandra I, Ono Daisuke, Wieczorek Mikolaj A, Johnson Patrick W, White Launia J, Watkins Molly M, Murray Melissa E, Kasanuki Koji, McLean Pamela J, Springer Wolfdieter, Uitti Ryan J, Fields Julie A, Botha Hugo, Ramanan Vijay K, Kantarci Kejal, Lowe Val J, Jack Clifford R, Bras Jose, Guerreiro Rita, Ertekin-Taner Nilufer, Savica Rodolfo, Graff-Radford Jonathan, Petersen Ronald C, Parisi Joseph E, Reichard R Ross, Graff-Radford Neill R, Ferman Tanis J, Boeve Bradley F, Wszolek Zbigniew K, Dickson Dennis W, Heckman Michael G, Ross Owen A

Abstract excerpt

Studies assessing genetic associations with neuropathological features in Lewy body disease (LBD) have been limited to candidate gene investigations, and therefore, information is lacking regarding the genetic architecture of the neuropathology of LBD. In the current study, we examined a large series of neuropathologically confirmed LBD cases (n = 980 in the discovery series, n = 503 in the replication series)...

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Identifiers

PMID: 40091616
DOI: 10.1093/brain/awaf105
PMCID: PMC12316003

Genes

APOE
ATF7IP2
GRIN2A
MCTP2
TLE3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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