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Article

Association of Apolipoprotein E ε4 With Transactive Response DNA-Binding Protein 43

26 Oct 2018

Abstract excerpt

Importance: Transactive response DNA-binding protein 43 (TDP-43) is associated with Alzheimer disease (AD), progressive hippocampal atrophy, and cognitive decline. The apolipoprotein E (APOE) ε4 allele is strongly associated with β-amyloid (Aβ) aggregation and risk of AD, but its association with TDP-43 is unknown. Objective: To determine whether the APOE ε4 allele is a risk factor for TDP-43. Design, Setting,...

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PMID: 30422173
DOI: 10.1001/jamaneurol.2018.3139

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