Article
TDP-43 proteinopathies: pathological identification of brain regions differentiating clinical phenotypes.
Brain : a journal of neurology - 1 Oct 2015
Tan Rachel H, Kril Jillian J, Fatima Manaal, McGeachie Andrew, McCann Heather, Shepherd Claire, Forrest Shelley L, Affleck Andrew, Kwok John B J, Hodges John R, Kiernan Matthew C, Halliday Glenda M
Abstract excerpt
The pathological sequestration of TAR DNA-binding protein 43 (TDP-43, encoded by TARDBP) into cytoplasmic pathological inclusions characterizes the distinct clinical syndromes of amyotrophic lateral sclerosis and behavioural variant frontotemporal dementia, while also co-occurring in a proportion of patients with Alzheimer's disease, suggesting that the regional concentration of TDP-43 pathology has most...
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