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Article

Proteome profiling of cerebrospinal fluid using machine learning shows a unique protein signature associated with APOE4 genotype.

Aging cell - 1 Apr 2025

Shvetcov Artur, Thomson Shannon, Cho Ann-Na, Wilkins Heather M, Reed Joanne H, Swerdlow Russell H, Brown David A, Finney Caitlin A

Abstract excerpt

Proteome changes associated with APOE4 variant carriage that are independent of Alzheimer's disease (AD) pathology and diagnosis are unknown. This study investigated APOE4 proteome changes in people with AD, mild cognitive impairment, and no impairment. Clinical, APOE genotype, and cerebrospinal fluid (CSF) proteome and AD biomarker data was sourced from the Alzheimer's Disease Neuroimaging Initiative (ADNI)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39722190
DOI: 10.1111/acel.14439
PMCID: PMC11984689

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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