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SAHH Deficiency Decreases Stability of Atherosclerotic Plaque and Induces VSMC Phenotype Switching via Epigenetic Upregulation of KLF4 and OCT4.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2026

Liu Si, Huang Ting, Pan Mingjun, Wang Yongyi, Dai Xin, Liu Chaoqun, Huang Haiyan, Ling Wenhua, Li Bo, He Yulong, Xiao Yunjun

Abstract excerpt

BACKGROUND: S-adenosylhomocysteine (SAH) is a novel risk factor of cardiovascular disease. SAHH (S-adenosylhomocysteine hydrolase) inhibition leads to SAH accumulation and promotes the formation and development of atherosclerosis. However, the role and underlying mechanism of SAHH in the stability of advanced atherosclerotic plaque are still unknown. METHODS: ApoE-deficient mice with heterozygous SAHH knockout or...

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Identifiers

PMID: 42131918
DOI: 10.1161/ATVBAHA.125.324115

Genes

KLF4
TET2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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