Article

The Link Between Hyperhomocysteinemia and Hypomethylation

2017-01-01

Abstract excerpt

Increased levels of homocysteine have been established as a risk factor for cardiovascular disease (CVD) by mechanisms still incompletely defined. S-Adenosylhomocysteine (SAH) is the metabolic precursor of homocysteine that accumulates in the setting of hyperhomocysteinemia and is a negative regulator of most cell methyltransferases. Several observations, summarized in the current review, support the concept that...

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Literature Corpus work: de989b0a-c59d-5024-a378-90889f7698a4
DOI: 10.1177/2326409817698994

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