Article

Desert hedgehog enhances endothelial resilience and prevents atherosclerosis by mitigating PAI-1 signaling

2026-06-06

Abstract excerpt

<h4>BACKGROUND</h4> Atherosclerotic cardiovascular disease remains the leading cause of death worldwide. Most current pharmacotherapies target conventional risk factors that promote atherosclerosis (e.g., hyperlipidemia) rather than intrinsic resilience factors that protect against atherosclerosis in the face of risk factors. Here, we investigated the role of desert hedgehog ( DHH ), a canonical ligand of the he...

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Literature Corpus work: 987a4814-eadd-58b5-ab8a-fbee624df7b9
DOI: 10.64898/2026.06.02.729715

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