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Article

SUV39H1 Regulates KLF4 and Chromatin Remodeling in Smooth Muscle Cell Phenotypic Plasticity.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2025

Chatterjee Payel, Chakraborty Raja, Sizer Ashley J, O'Brien Brendan J, Xu Peng, Hwa Jonathan M, Xie Yi, Yan Qin, Hwa John, Martin Kathleen A

Abstract excerpt

BACKGROUND: Reversible DNA methylation contributes to vascular smooth muscle cell (VSMC) phenotypic plasticity. This plasticity contributes to vascular growth and remodeling but also underlies pathologies, including intimal hyperplasia. We investigated the role of SUV39H1 (suppressor of variegation 3-9 homolog 1), a histone methyltransferase that generates trimethylation at histone H3 lysine 9 (H3K9me3), a...

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Source

Identifiers

PMID: 40836920
DOI: 10.1161/ATVBAHA.124.322179

Genes

SUV39H1
KLF4
KDM4A
DNMT1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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SUV39H1 Regulates KLF4 and Chromatin Remodeling in Smooth Muscle Cell Phenotypic Plasticity.PMID 40836920Read ↗

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