Article

SUV39H1 mediated regulation of KLF4 and KDM4A coordinate smooth muscle cell phenotypic plasticity

2024-11-03

Abstract excerpt

<h4>Background</h4> Reversible DNA methylation contributes to the phenotypic plasticity of vascular smooth muscle cells (VSMCs). This plasticity contributes to vascular growth remodeling, but also underlies cardiovascular pathologies, including intimal hyperplasia. We investigated the role of SUV39H1, a histone methyltransferase that generates the H3K9me3 repressive epigenetic mark, in VSMC plasticity <h4>Methods...

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Literature Corpus work: 1adb9586-e985-5c73-b663-0a4a56960ce3
DOI: 10.1101/2024.11.03.621725

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