Cognitive and Neuroanatomical Effects of Fatty Acid Amide Hydrolase Polymorphism rs324420 in Aging and Alzheimer Disease.

doi:10.1097/WAD.0000000000000723

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Cognitive and Neuroanatomical Effects of Fatty Acid Amide Hydrolase Polymorphism rs324420 in Aging and Alzheimer Disease.

Alzheimer disease and associated disorders - 1 Jan 2026

Mori-Fegan Daniel K, Wong Yuen Yan, Noor Shiropa, Wu Che-Yuan, Ryoo Siwon, Mielnik Catharine, Ross Ruth A, Swardfager Walter

Abstract excerpt

INTRODUCTION: Therapeutic options for Alzheimer disease (AD) are limited. Modulating the endocannabinoid system through fatty acid amide hydrolase (FAAH) is a promising target. We investigated how the FAAH functional polymorphism rs324420 influences cognition and brain structure across the AD continuum, particularly in interaction with amyloid (Aβ) pathology. METHODS: One thousand, five hundred seven Alzheimer...

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PMID: 42127232
DOI: 10.1097/WAD.0000000000000723

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FAAH

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