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Article

Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease.

Neurobiology of aging - 1 Jan 2018

Mecca Adam P, Barcelos Nicole M, Wang Shuo, Brück Anna, Nabulsi Nabeel, Planeta-Wilson Beata, Nadelmann Jennifer, Benincasa Amanda L, Ropchan Jim, Huang Yiyun, Gelernter Joel, Van Ness Peter H, Carson Richard E, van Dyck Christopher H

Abstract excerpt

Models of preclinical Alzheimer's disease (AD) propose that cerebral amyloidosis leads to neurodegeneration and subsequent cognitive decline. This study investigated whether APOE genotype is related to β-amyloid (Aβ) burden in brain regions preferentially affected by AD and whether Aβ burden is associated with gray-matter (GM) fraction (as a marker of neurodegeneration) and episodic memory performance in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29111487
DOI: 10.1016/j.neurobiolaging.2017.09.027
PMCID: PMC5722236

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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