ABCA7 rs115550680 risk allele carriers have lower medial temporal lobe dynamic network flexibility than APOE-ε4 allele carriers among older African Americans.

doi:10.1016/j.neurobiolaging.2026.01.008

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Article

ABCA7 rs115550680 risk allele carriers have lower medial temporal lobe dynamic network flexibility than APOE-ε4 allele carriers among older African Americans.

Neurobiology of aging - 1 May 2026

Budak Miray, Fausto Bernadette A, Paruzel Victoria, White Payton, Ishaq Martina, Moallemian Soodeh, Nudelman Kelly N, Gluck Mark A

Abstract excerpt

Alzheimer's disease (AD) pathology disrupts functional brain connectivity long before symptoms emerge. African Americans face elevated AD risk, yet underlying mechanisms remain unclear. Genetic risk differs by ancestry: APOE-ε4 strongly predicts late-onset AD in European ancestry, whereas ABCA7 rs115550680 confers substantial risk in African ancestry. Yet, how these variants influence neural function in African...

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Identifiers

PMID: 41637763
DOI: 10.1016/j.neurobiolaging.2026.01.008
PMCID: PMC13080515

Genes

APOE
ABCA7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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