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Metabolic Alteration in Oxylipins and Endocannabinoids Point to an Important Role for Soluble Epoxide Hydrolase and Inflammation in Alzheimer’s Disease - Finding from Alzheimer’s Disease Neuroimaging Initiative

2025-04-03

Abstract excerpt

Mounting evidence implicates inflammation as a key factor in Alzheimer’s disease (AD) development. We previously identified pro-inflammatory soluble epoxide hydrolase (sEH) metabolites to be elevated in plasma and CSF of AD patients and to be associated with lower cognition in non-AD subjects. Soluble epoxide hydrolase is a key enzyme converting anti-inflammatory epoxy fatty acids to pro-inflammatory diols, report...

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Literature Corpus work: da7ffaa7-1539-529d-9793-a2b8cefebe1b
DOI: 10.1101/2025.04.01.646677

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