APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies.

doi:10.1002/alz.12538

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Article

APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2022

Wang Tingting, Huynh Kevin, Giles Corey, Mellett Natalie A, Duong Thy, Nguyen Anh, Lim Wei Ling Florence, Smith Alex At, Olshansky Gavriel, Cadby Gemma, Hung Joseph, Hui Jennie, Beilby John, Watts Gerald F, Chatterjee Pratishtha, Martins Ian, Laws Simon M, Bush Ashley I, Rowe Christopher C, Villemagne Victor L, Ames David, Masters Colin L, Taddei Kevin, Doré Vincent, Fripp Jürgen, Arnold Matthias, Kastenmüller Gabi, Nho Kwangsik, Saykin Andrew J, Baillie Rebecca, Han Xianlin, Martins Ralph N, Moses Eric K, Kaddurah-Daouk Rima, Meikle Peter J

Abstract excerpt

INTRODUCTION: The apolipoprotein E (APOE) genotype is the strongest genetic risk factor for late-onset Alzheimer's disease. However, its effect on lipid metabolic pathways, and their mediating effect on disease risk, is poorly understood. METHODS: We performed lipidomic analysis on three independent cohorts (the Australian Imaging, Biomarkers and Lifestyle [AIBL] flagship study, n = 1087; the Alzheimer's Disease...

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PMID: 35077012
DOI: 10.1002/alz.12538
PMCID: PMC9787288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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