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The blood lipidome fatty acid profile predicts the disease risk and clinical phenotypes of Alzheimer's disease: associations from two prospective cohort studies.

Translational psychiatry - 6 Oct 2025

Liu Wen-Zheng, Huang Liang-Yu, Chi Song, Ma Ya-Hui, Tan Chen-Chen, Tan Lan, Xu Wei

Abstract excerpt

The relationship between fatty acids and Alzheimer's Disease (AD) risk has been an area of growing interest but remains insufficiently understood. This study aimed to develop and validate a fatty acid score (FAS) derived from blood fatty acid levels and explore its association with AD risk. We analyzed 148,308 UK Biobank participants (age 37-73; mean 55.96 years) with a mean follow-up of 12.3 years (maximum 16),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41052990
DOI: 10.1038/s41398-025-03526-w
PMCID: PMC12500968

Genes

FAS
APOE
ADGRG1
CHI3L1
GDF15
RBFOX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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