Exploring Intratumor Heterogeneity in Cancer: A Comparative Evaluation of Clustering Methods.

Abstract excerpt

Intratumor heterogeneity (ITH) impacts cancer progression, and its characterization is crucial. Clustering algorithms applied to the variant allele frequency (VAF) of mutations can facilitate the exploratory analysis of ITH. This study comparatively evaluated six clustering algorithms to characterize ITH by clustering mutations based on their VAFs. We utilized data from The Cancer Genome Atlas to analyze three...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Bayes Theorem