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Article

Accurate Identification of Subclones in Tumor Genomes.

Molecular biology and evolution - 2 Jul 2022

Ahmadinejad Navid, Troftgruben Shayna, Wang Junwen, Chandrashekar Pramod B, Dinu Valentin, Maley Carlo, Liu Li

Abstract excerpt

Understanding intratumor heterogeneity is critical for studying tumorigenesis and designing personalized treatments. To decompose the mixed cell population in a tumor, subclones are inferred computationally based on variant allele frequency (VAF) from bulk sequencing data. In this study, we showed that sequencing depth, mean VAF, and variance of VAF of a subclone are confounded. Without considering this effect,...

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Identifiers

PMID: 35749590
DOI: 10.1093/molbev/msac136
PMCID: PMC9260306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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