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Article

DITHER: an algorithm for Defining IntraTumor Heterogeneity based on EntRopy.

Briefings in bioinformatics - 5 Nov 2021

Li Lin, Chen Canping, Wang Xiaosheng

Abstract excerpt

Intratumor heterogeneity (ITH) is associated with tumor development, prognosis, immune evasion and therapeutic effects. We proposed the Defining ITH based on EntRopy (DITHER) algorithm for evaluating ITH. We first evaluated the entropies of somatic mutation profiles and copy number alteration (CNA) profiles in a tumor, respectively, and defined their average as the ITH level for the tumor. Using DITHER, we...

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Identifiers

PMID: 34096997
DOI: 10.1093/bib/bbab202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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