Article
A novel framework for analyzing somatic copy number aberrations and tumor subclones for paired heterogeneous tumor samples.
Bio-medical materials and engineering - 1 Jan 2015
Xia Hong, Li Ao, Yu Zhenhua, Liu Xiaocheng, Feng Huanqing
Abstract excerpt
Application of the Next generation sequencing (NGS) technology has demonstrated that most tumor samples exhibit intra-tumor heterogeneity. Here we proposed SAPPH (Somatic Aberrations Prediction for Paired Heterogeneous tumor samples), as a new method for estimating tumor somatic copy number aberrations as well as inferring tumor subclone proportions from heterogeneous tumor sequencing data. This method is based...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.