Article

Accurate detection of tumor clonality and ongoing expansion mode from genomic data

2026-06-19

Abstract excerpt

Recent evidence shows that despite considerable effort, currently available algorithms for estimating intratumor heterogeneity (ITH) remain limited. We developed DECODE ( De ciphering C ancer O rigin from D NA E volution), a novel mutation clustering method that incorporates the impact of sample-specific sequencing coverage and mutation calling biases. On synthetic data, DECODE outperformed existing methods a...

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Literature Corpus work: 14ec619a-44f4-5e19-b606-f6389aff1d41
DOI: 10.64898/2026.06.15.732415

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