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Article

Single-cell transcriptomic analysis reveals APOE genotype-dependent sex differences in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2026

Yu Gefei, Thorpe Abigail, Zeng Qi, Wang Erming, Goate Alison, Cai Dongming, Wang Minghui, Zhang Bin

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) is the most common form of dementia, with approximately two-thirds of AD patients being female. Basic and clinical research studies provide strong evidence that sex-specific differences contribute to AD complexity. Additionally, sex-specific interactions between apolipoprotein E (APOE) 𝜀4, the primary genetic risk factor of AD, and AD-associated neurodegenerative processes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42108391
DOI: 10.1002/alz.71463
PMCID: PMC13158137

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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