Sex-stratified single-cell RNA-Seq analysis identifies sex-specific and cell type-specific transcriptional responses in Alzheimer’s disease across two brain regions.

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s disease (AD) is a pervasive neurodegenerative disorder that disproportionately affects women. Since neural anatomy and disease pathophysiology differ by sex, investigating sex-specific mechanisms in AD pathophysiology can inform new therapeutic approaches for both sexes. Here, we utilized nearly 74,000 cells from human prefrontal and entorhinal cortex samples from the first...

Topics

Open a Topic to create a Post that cites this publication.

• Alzheimer Disease
• Apolipoproteins E
• Brain
• Gene Expression Profiling
• Sex Characteristics
• Single-Cell Analysis
• Single-Cell Gene Expression Analysis
• Transcriptome

Identifiers and source

Literature Corpus work

2562563a-72eb-5cbd-b255-a5326fd6adc6

DOI

10.21203/rs.3.rs-418653/v1