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Sex‐dependent molecular landscape of Alzheimer's disease revealed by large‐scale single‐cell transcriptomics

31 Dec 2024

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) shows significant sex differences in prevalence and clinical manifestations, but the underlying molecular mechanisms remain unclear. METHODS: This study used a large-scale, single-cell transcriptomic atlas of the human prefrontal cortex to investigate sex-dependent molecular changes in AD. Our approach combined cell type-specific and sex-specific differential gene expression...

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PMID: 39737748
DOI: 10.1002/alz.14476

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