Article
Steric hindrance of antibody binding in an Omicron spike fusion intermediate.
Nature - 1 Jun 2026
Bao Zhiheng, Liu Zhimin, Zhang Zhaoyong, Wang Xuanjia, Jin Xiaohui, Bai Jiaxiu, Ma Hanwen, Li Yaxin, Yi Chunyan, Ling Zhiyang, Huang Zhong, Zhang Lu, Chen Zhenguo, Xie Youhua, Wang Yanqun, Sun Lei, Sun Xiaoyu
Abstract excerpt
Understanding conformational changes of the coronavirus spike protein is critical for developing broad-spectrum therapies. The pan-coronavirus epitope spike residues 815-825 (centred on the S2' site) are buried in the prefusion spike but are transiently exposed upon ACE2 binding1,2. Here, using integrated functional and structural analyses, we demonstrate that 76E1, an antibody targeting spike residues 815-825,...
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