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Article

Antibody escape and cryptic cross-domain stabilization in the SARS-CoV-2 Omicron spike protein.

Cell host & microbe - 14 Sept 2022

Javanmardi Kamyab, Segall-Shapiro Thomas H, Chou Chia-Wei, Boutz Daniel R, Olsen Randall J, Xie Xuping, Xia Hongjie, Shi Pei-Yong, Johnson Charlie D, Annapareddy Ankur, Weaver Scott, Musser James M, Ellington Andrew D, Finkelstein Ilya J, Gollihar Jimmy D

Abstract excerpt

The worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the repeated emergence of variants of concern. For the Omicron variant, sub-lineages BA.1 and BA.2, respectively, contain 33 and 29 nonsynonymous and indel spike protein mutations. These amino acid substitutions and indels are implicated in increased transmissibility and enhanced immune evasion. By reverting individual...

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Identifiers

PMID: 35988543
DOI: 10.1016/j.chom.2022.07.016
PMCID: PMC9350683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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