Article

ACE2 engagement exposes the fusion peptide to pan-coronavirus neutralizing antibodies

2022-03-30

Abstract excerpt

Coronaviruses use diverse Spike (S) glycoproteins to attach to host receptors and fuse with target cells. Using a broad screening approach, we isolated from SARS-CoV-2 immune donors seven monoclonal antibodies (mAbs) that bind to all human alpha and beta coronavirus S proteins. These mAbs recognize the fusion peptide and acquire high affinity and breadth through somatic mutations. Despite targeting a conserved mot...

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Literature Corpus work: 112aeb97-86ab-5ea5-81bc-34f33231eeea
DOI: 10.1101/2022.03.30.486377

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