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Article

Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses

7 Mar 2023

Abstract excerpt

To address the ongoing SARS-CoV-2 pandemic and prepare for future coronavirus outbreaks, understanding the protective potential of epitopes conserved across SARS-CoV-2 variants and coronavirus lineages is essential. We describe a highly conserved, conformational S2 domain epitope present only in the prefusion core of β-coronaviruses: SARS-CoV-2 S2 apex residues 980-1006 in the flexible hinge. Antibody RAY53 binds...

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PMID: 36942851
DOI: 10.7554/elife.83710

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