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Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein.

Nature communications - 14 Mar 2023

Calvaresi Valeria, Wrobel Antoni G, Toporowska Joanna, Hammerschmid Dietmar, Doores Katie J, Bradshaw Richard T, Parsons Ricardo B, Benton Donald J, Roustan Chloë, Reading Eamonn, Malim Michael H, Gamblin Steve J, Politis Argyris

Abstract excerpt

SARS-CoV-2 spike glycoprotein mediates receptor binding and subsequent membrane fusion. It exists in a range of conformations, including a closed state unable to bind the ACE2 receptor, and an open state that does so but displays more exposed antigenic surface. Spikes of variants of concern (VOCs) acquired amino acid changes linked to increased virulence and immune evasion. Here, using HDX-MS, we identified...

Topics

Humans
Spike Glycoprotein, Coronavirus
Angiotensin-Converting Enzyme 2
COVID-19
SARS-CoV-2
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36918534
DOI: 10.1038/s41467-023-36745-0
PMCID: PMC10013288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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