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SARS-CoV-2 Omicron Variant Spike Glycoprotein Mutation Q954H Enhances Fusion Core Stability.

ACS chemical biology - 18 Jul 2025

Vithanage Nisansala, Apurba Rifat Hasan, Ozomarisi Hamza Enesi, Bair Carson J, Sugg Eve L, Outlaw Victor K

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant-of-concern has rapidly spread across the globe to become the dominant form of COVID-19 infection. The Omicron Spike (S) glycoprotein, which mediates viral entry into cells, possesses up to 34 mutations that contribute to the variant's increased transmissibility and decreased susceptibility to antibody-mediated immunity from vaccines...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40619650
DOI: 10.1021/acschembio.5c00208

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